The application of halloysite tubule nanoclay in drug delivery.
Identifieur interne : 000136 ( Main/Exploration ); précédent : 000135; suivant : 000137The application of halloysite tubule nanoclay in drug delivery.
Auteurs : Yuri M. Lvov [États-Unis, Russie] ; Melgardt M. Devilliers [États-Unis] ; Rawil F. Fakhrullin [Russie]Source :
- Expert opinion on drug delivery [ 1744-7593 ] ; 2016.
Descripteurs français
- KwdFr :
- Argile (MeSH), Chimie pharmaceutique (MeSH), Libération de médicament (MeSH), Nanotubes (composition chimique), Polymères (composition chimique), Préparations à action retardée (MeSH), Silicates d'aluminium (composition chimique), Silice (composition chimique), Structures d'échafaudage tissulaires (MeSH), Systèmes de délivrance de médicaments (MeSH).
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Aluminum Silicates, Polymers, Silicon Dioxide.
- chemistry : Nanotubes.
- Chemistry, Pharmaceutical, Clay, Delayed-Action Preparations, Drug Delivery Systems, Drug Liberation, Tissue Scaffolds.
Abstract
INTRODUCTION
Natural and biocompatible clay nanotubes are among the best inorganic materials for drug nanoformulations. These halloysite tubes with SiO2 on the outermost surface have diameter of ca. 50 nm, length around 1 micrometer and may be loaded with drugs at 10-30 wt. %. Narrow tube openings allow for controllable sustained drug release for hours, days or even weeks.
AREAS COVERED
Physical-chemical properties of these nanotubes are described followed by examples of drug-loading capabilities, release characteristics, and control of duration of release through the end tube capping with polymers. Development of halloysite-polymer composites such as tissue scaffolds and bone cement/dentist resin formulations with enhanced mechanical properties and extension of the drug release to 2-3 weeks are described. Examples of the compression properties of halloysite in tablets and capsules are also shown.
EXPERT OPINION
We expect that clay nanotubes will be used primarily for non-injectable drug formulations, such as topical and oral dosage forms, cosmetics, as well as for composite materials with enhanced therapeutic effects. These include tissue scaffolds, bone cement and dentist resins with sustained release of antimicrobial and cell growth-promoting medicines (including proteins and DNA) as well as other formulations such as compounds for antiseptic treatment of hospitals.
DOI: 10.1517/17425247.2016.1169271
PubMed: 27027933
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Lvov</name><affiliation wicri:level="2"><nlm:affiliation>a Biomedical Engineering Program and Institute for Micromanufacturing , Louisiana Tech University , Ruston , LA , USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>a Biomedical Engineering Program and Institute for Micromanufacturing , Louisiana Tech University , Ruston , LA </wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>c Institute of Fundamental Medicine and Biology , Kazan Federal University , Tatarstan , Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>c Institute of Fundamental Medicine and Biology , Kazan Federal University , Tatarstan </wicri:regionArea><wicri:noRegion>Tatarstan </wicri:noRegion></affiliation></author><author><name sortKey="Devilliers, Melgardt M" sort="Devilliers, Melgardt M" uniqKey="Devilliers M" first="Melgardt M" last="Devilliers">Melgardt M. 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Lvov</name><affiliation wicri:level="2"><nlm:affiliation>a Biomedical Engineering Program and Institute for Micromanufacturing , Louisiana Tech University , Ruston , LA , USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>a Biomedical Engineering Program and Institute for Micromanufacturing , Louisiana Tech University , Ruston , LA </wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>c Institute of Fundamental Medicine and Biology , Kazan Federal University , Tatarstan , Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>c Institute of Fundamental Medicine and Biology , Kazan Federal University , Tatarstan </wicri:regionArea><wicri:noRegion>Tatarstan </wicri:noRegion></affiliation></author><author><name sortKey="Devilliers, Melgardt M" sort="Devilliers, Melgardt M" uniqKey="Devilliers M" first="Melgardt M" last="Devilliers">Melgardt M. Devilliers</name><affiliation wicri:level="2"><nlm:affiliation>b School of Pharmacy , University of Wisconsin , Madison , WI , USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>b School of Pharmacy , University of Wisconsin , Madison , WI </wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Fakhrullin, Rawil F" sort="Fakhrullin, Rawil F" uniqKey="Fakhrullin R" first="Rawil F" last="Fakhrullin">Rawil F. Fakhrullin</name><affiliation wicri:level="1"><nlm:affiliation>c Institute of Fundamental Medicine and Biology , Kazan Federal University , Tatarstan , Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>c Institute of Fundamental Medicine and Biology , Kazan Federal University , Tatarstan </wicri:regionArea><wicri:noRegion>Tatarstan </wicri:noRegion></affiliation></author></analytic><series><title level="j">Expert opinion on drug delivery</title><idno type="eISSN">1744-7593</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aluminum Silicates (chemistry)</term><term>Chemistry, Pharmaceutical (MeSH)</term><term>Clay (MeSH)</term><term>Delayed-Action Preparations (MeSH)</term><term>Drug Delivery Systems (MeSH)</term><term>Drug Liberation (MeSH)</term><term>Nanotubes (chemistry)</term><term>Polymers (chemistry)</term><term>Silicon Dioxide (chemistry)</term><term>Tissue Scaffolds (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Argile (MeSH)</term><term>Chimie pharmaceutique (MeSH)</term><term>Libération de médicament (MeSH)</term><term>Nanotubes (composition chimique)</term><term>Polymères (composition chimique)</term><term>Préparations à action retardée (MeSH)</term><term>Silicates d'aluminium (composition chimique)</term><term>Silice (composition chimique)</term><term>Structures d'échafaudage tissulaires (MeSH)</term><term>Systèmes de délivrance de médicaments (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Aluminum Silicates</term><term>Polymers</term><term>Silicon Dioxide</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Nanotubes</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Nanotubes</term><term>Polymères</term><term>Silicates d'aluminium</term><term>Silice</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Chemistry, Pharmaceutical</term><term>Clay</term><term>Delayed-Action Preparations</term><term>Drug Delivery Systems</term><term>Drug Liberation</term><term>Tissue Scaffolds</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Argile</term><term>Chimie pharmaceutique</term><term>Libération de médicament</term><term>Préparations à action retardée</term><term>Structures d'échafaudage tissulaires</term><term>Systèmes de délivrance de médicaments</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b></p><p>Natural and biocompatible clay nanotubes are among the best inorganic materials for drug nanoformulations. These halloysite tubes with SiO2 on the outermost surface have diameter of ca. 50 nm, length around 1 micrometer and may be loaded with drugs at 10-30 wt. %. Narrow tube openings allow for controllable sustained drug release for hours, days or even weeks.</p></div><div type="abstract" xml:lang="en"><p><b>AREAS COVERED</b></p><p>Physical-chemical properties of these nanotubes are described followed by examples of drug-loading capabilities, release characteristics, and control of duration of release through the end tube capping with polymers. Development of halloysite-polymer composites such as tissue scaffolds and bone cement/dentist resin formulations with enhanced mechanical properties and extension of the drug release to 2-3 weeks are described. Examples of the compression properties of halloysite in tablets and capsules are also shown.</p></div><div type="abstract" xml:lang="en"><p><b>EXPERT OPINION</b></p><p>We expect that clay nanotubes will be used primarily for non-injectable drug formulations, such as topical and oral dosage forms, cosmetics, as well as for composite materials with enhanced therapeutic effects. These include tissue scaffolds, bone cement and dentist resins with sustained release of antimicrobial and cell growth-promoting medicines (including proteins and DNA) as well as other formulations such as compounds for antiseptic treatment of hospitals.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">27027933</PMID><DateCompleted><Year>2017</Year><Month>06</Month><Day>08</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1744-7593</ISSN><JournalIssue CitedMedium="Internet"><Volume>13</Volume><Issue>7</Issue><PubDate><Year>2016</Year><Month>07</Month></PubDate></JournalIssue><Title>Expert opinion on drug delivery</Title><ISOAbbreviation>Expert Opin Drug Deliv</ISOAbbreviation></Journal><ArticleTitle>The application of halloysite tubule nanoclay in drug delivery.</ArticleTitle><Pagination><MedlinePgn>977-86</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1517/17425247.2016.1169271</ELocationID><Abstract><AbstractText Label="INTRODUCTION">Natural and biocompatible clay nanotubes are among the best inorganic materials for drug nanoformulations. These halloysite tubes with SiO2 on the outermost surface have diameter of ca. 50 nm, length around 1 micrometer and may be loaded with drugs at 10-30 wt. %. Narrow tube openings allow for controllable sustained drug release for hours, days or even weeks.</AbstractText><AbstractText Label="AREAS COVERED">Physical-chemical properties of these nanotubes are described followed by examples of drug-loading capabilities, release characteristics, and control of duration of release through the end tube capping with polymers. Development of halloysite-polymer composites such as tissue scaffolds and bone cement/dentist resin formulations with enhanced mechanical properties and extension of the drug release to 2-3 weeks are described. Examples of the compression properties of halloysite in tablets and capsules are also shown.</AbstractText><AbstractText Label="EXPERT OPINION">We expect that clay nanotubes will be used primarily for non-injectable drug formulations, such as topical and oral dosage forms, cosmetics, as well as for composite materials with enhanced therapeutic effects. These include tissue scaffolds, bone cement and dentist resins with sustained release of antimicrobial and cell growth-promoting medicines (including proteins and DNA) as well as other formulations such as compounds for antiseptic treatment of hospitals.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lvov</LastName><ForeName>Yuri M</ForeName><Initials>YM</Initials><AffiliationInfo><Affiliation>a Biomedical Engineering Program and Institute for Micromanufacturing , Louisiana Tech University , Ruston , LA , USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>c Institute of Fundamental Medicine and Biology , Kazan Federal University , Tatarstan , Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>DeVilliers</LastName><ForeName>Melgardt M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>b School of Pharmacy , University of Wisconsin , Madison , WI , USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fakhrullin</LastName><ForeName>Rawil F</ForeName><Initials>RF</Initials><AffiliationInfo><Affiliation>c Institute of Fundamental Medicine and Biology , Kazan Federal University , Tatarstan , Russia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>04</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Expert Opin Drug Deliv</MedlineTA><NlmUniqueID>101228421</NlmUniqueID><ISSNLinking>1742-5247</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000538">Aluminum Silicates</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003692">Delayed-Action Preparations</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011108">Polymers</NameOfSubstance></Chemical><Chemical><RegistryNumber>7631-86-9</RegistryNumber><NameOfSubstance UI="D012822">Silicon Dioxide</NameOfSubstance></Chemical><Chemical><RegistryNumber>T1FAD4SS2M</RegistryNumber><NameOfSubstance UI="D000077215">Clay</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000538" MajorTopicYN="N">Aluminum Silicates</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002626" MajorTopicYN="N">Chemistry, Pharmaceutical</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000077215" MajorTopicYN="N">Clay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003692" MajorTopicYN="N">Delayed-Action Preparations</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016503" MajorTopicYN="Y">Drug Delivery Systems</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D065546" MajorTopicYN="N">Drug Liberation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D043942" MajorTopicYN="N">Nanotubes</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011108" MajorTopicYN="N">Polymers</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012822" MajorTopicYN="N">Silicon Dioxide</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D054457" MajorTopicYN="N">Tissue Scaffolds</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Clay nanotubes</Keyword><Keyword MajorTopicYN="Y">drug sustained release</Keyword><Keyword MajorTopicYN="Y">halloysite tablets</Keyword><Keyword MajorTopicYN="Y">nanosafety</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>3</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>3</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>6</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27027933</ArticleId><ArticleId IdType="doi">10.1517/17425247.2016.1169271</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Russie</li><li>États-Unis</li></country><region><li>Louisiane</li><li>Wisconsin</li></region></list><tree><country name="États-Unis"><region name="Louisiane"><name sortKey="Lvov, Yuri M" sort="Lvov, Yuri M" uniqKey="Lvov Y" first="Yuri M" last="Lvov">Yuri M. Lvov</name></region><name sortKey="Devilliers, Melgardt M" sort="Devilliers, Melgardt M" uniqKey="Devilliers M" first="Melgardt M" last="Devilliers">Melgardt M. Devilliers</name></country><country name="Russie"><noRegion><name sortKey="Lvov, Yuri M" sort="Lvov, Yuri M" uniqKey="Lvov Y" first="Yuri M" last="Lvov">Yuri M. Lvov</name></noRegion><name sortKey="Fakhrullin, Rawil F" sort="Fakhrullin, Rawil F" uniqKey="Fakhrullin R" first="Rawil F" last="Fakhrullin">Rawil F. Fakhrullin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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